DEPARTMENT OF HUMAN GENETICS / UNIVERSITY OF CHICAGOhttp://genes.uchicago.eduhttp://www.uchicago.edushapeimage_1_link_0shapeimage_1_link_1
Gilad Labhttp://giladlab.uchicago.edushapeimage_2_link_0

One of the main challenges for human geneticists in the ‘post-genome’ era is to understand the genetic architecture of gene regulation and how differences in gene regulation affect complex phenotypes, including human diseases. While many groups are studying gene regulatory mechanisms in model organisms, we reasoned that, although more challenging, the study of gene regulation in primates may carry rewards that are immediately applicable to humans. By collecting valuable samples, developing and adapting new technologies, and combining expertise in evolutionary biology, comparative genetics, and genomics, our lab has made key contributions to the study of gene regulation in humans. Recently we have also started to work with human and non-human primate induced pluripotent stem cells.

A summary of our recent research is available here.

We are currently pursuing the following studies (click for more details):

Using iPSC to study primate evolution

The evolution of protein regulation

Mapping eQTLs associated with CVD risk

Mapping response eQTLs for MTB infection

Understanding genetic determinants of regulatory variation

Copyright © Yoav Gilad


Cummings Life Science Center

920 E. 58th Street, CLSC 317

Chicago, IL 60637, USA

Office: (773) 702-8507

Lab: (773) 834-1984

Fax: (773) 834-8470

Tamiko Charley (assistant)

Phone: (773) 834-5304

E-mail: tcharley ~